Friday, May 26, 2000

Registration

Saturday, May 27, 2000

Opening Addresses

Cell Signaling by Protein Phosphorylation I
Chair: Carl-Henrik Heldin

Signal transduction involving the Src family and other tyrosine kinases
S. A. Courtneidge, USA

Transmembrane signaling by protein-tyrosine kinases and phosphatases
T. Hunter, USA

Cellular signaling by tyrosine phosphorylation
J. Schlessinger, USA 

Molecular signaling networks in health and disease
A. Ullrich, Germany

Protein modules in signal transduction
A. J. Pawson, Canada

Poster Session (Cell Signaling by Protein Phosphorylation) & Coffee Break

Cell Signaling by Protein Phosphorylation II
Chair: Sara A. Courtneidge

Signal transduction via receptors for PDGF and TGF-beta
C.-H. Heldin, Sweden

Protein kinase cascades and the activation of innate immunity and inflammation
M. Karin, USA

Protein kinase B/Akt at the crossroads of diabetes, cancer and neurodegeneration
B. A. Hemmings, Switzerland

Specificity of receptor tyrosine kinase. Signalling through interaction with specific adapter proteins
W. Birchmeier, Germany

Welcome Reception

Sunday, May 28, 2000

Signaling and Cancer
Chair: Tony Hunter

Signal transduction events regulated by integrin adhesion receptors
J. Brugge, USA

Cell adhesion and angiogenesis
E. Ruoslahti, USA

Scatter factor and semaphorin receptors: a gene superfamily controlling invasive growth
P. Comoglio, Italy 

Poster Session (Signaling and Cancer)

Keynote Lecture
The many roles of NF-kappa B
D. Baltimore, USA (Nobel Prize Laureate)

Signaling and Cancer II
Chair: Joan Brugge

Small GTPases and cell cycle control
C. Marshall, UK

Cell cycle and cancer: In vivo role of cyclin dependent kinases
M. Barbacid, Spain

Involvement of ring finger and SH2-ring intervening sequences in Cbl transformation
W. Langdon, Australia

Excursion to Dubrovnik

Reception at the Mayor's office

Monday, May 29, 2000

Cell Signaling in Development and Disease I
Chair: Julian Downward

Regulation of signal transduction in endothelial cells
L. Claesson-Welsh, Sweden

Bidirectional signaling by ephrins and Eph receptors in mouse neural development and angiogenesis
R. Klein, Germany

Regulation of neuronal production, migration and differentiation by the intercellular signaling
P. Rakic, USA 

Functional analysis of AP-1 (Fos/Jun) in mice
E. Wagner, Austria

Insulin signaling and growth control on Drosophila
E. Hafen (G. Oldham), Switzerland

Poster Session (Cell Signaling in Development and Disease, Cell Cycle and Apoptosis)

Cell Signaling in Development and Disease II
Chair: Erwin Wagner

Regulation of cytokine signaling in development and differentiation
J. N. Ihle, USA

Lipid oxidation products and fibrogenic cytokine expression
G. Poli, Italy 

STAT and IRF transcription factors in host defense
D. Levy, USA

Gab2 and SHP-2 in hematopoietic cell signaling
B. Neel, USA

SELECTED TALK

Cognitive improvement following treatment of Alzheimer's disease with stabilized oral NADH: Report on two 6-month placebo-controlled, double-blind studies
G. G. Kay, V. N. Starbuck, V. Demarin, S. Podobnik, D. Storga-Tomic and J.G.D. Birkmayer, USA

Tuesday, May 30, 2000

Selected Topics
Chair: David Levy

SELECTED TALKS

Opposing functions of Ki and Ha-Ras genes in the regulation of redox signals: a fraction of Ki Ras is localized in mitochondria
M. R. Santillo, G. Cuda, R. Paterno, A. Feliciello, S. Cassano, V. Martignatti, G. Diez-Roux and E. Avvedimento, Italy

Identification of ERBIN, a novel adaptor for the ERBB2/HER2 receptor
F. Jaulin-Bastard, H. Saito, S. Marchetto, A. Le Bivic, V. Ollendorff, B. Margolis, D. Birnbaum and J.-P. Borg , France

Expression and regulation of cortactin in human breast cancer
R. Daly, D. Campbell, D. Lynch, R. Hui and R. Sutherland, Australia

Chemokine receptor (CXCR4, CCR5) antagonists as anti-HIV agents
E. De Clercq, Belgium

Tyrosine phosphatase epsilon is required for myelination of peripheral nerves in post-natal mice
A. Elson, B. Attali, A. Peretz, H. Gil-Henn, A. Sobko and V. Shinder, Israel

The role of Presenilin and the SERCA-type Ca2+-ATPase in Notch receptor trafficking and proteolysis
M. E. Fortini, G. Periz, Y. Ye and N. I. Lukinova, USA

In vivo functions of JunB during myeloid development
E. Passegué, W. Jochum, M. Schorpp-Kistner, U. Möhle-Steinlein and E.F. Wagner, Austria

Cell Cycle and Apoptosis
Chair: Chris Marshall

Keynote Lecture
The proteasome and ATP-dependent proteolysis
R. Huber, Germany (Nobel Prize Laureate)

Protein kinases regulating cell division
E. Nigg, Germany

Identification of components of the cell death pathway
V. M. Dixit, USA

Pathways involved in the regulation of cell survival by oncogenes 
J. Downward, UK

Concluding Remarks & Complimentary Drink

Farewell Dinner