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Scientific program 2008
May 29 | May 30 | May 31 | June 1 | June 2 |June 3 | June 4
| May 29 |
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| 16:00 |
Arrival and registration |
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| 20:00 |
Welcome Reception |
| May 30 |
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Session I. From Bench to Bedside on Cancer Treatment
Chair: Giulio Superti-Furga, Austria |
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sponsored by  |
| 09:00-09:15 |
Opening remarks
Ivan Dikic, Manuela Baccarini, Joseph Schlessinger |
| 09:15-10:00 |
Joseph Schlessinger, USA
Cell signaling by receptor tyrosine kinases: from basic principles to Cancer Therapy |
10:00-10:30 |
Paul Manley, Switzerland
Nilotinib: From bench to bedside of a new therapy for chronic myelogenous leukaemia (CML)
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| 10:30-11:00 |
Coffee break |
11:00-11:30 |
Pier Paolo di Fiore, Italy
Numb controls the stem cell compartment in the normal breast gland and it is subverted in breast tumors |
| 11:30-11:50 |
Andree Blaukat, Germany
c-Met as a target for cancer therapy – discovery of new highly selective tyrosine kinase inhibitors |
| 11:50-12:10 |
Domagoj Vucic, USA
Targeting IAPs: TNFαlpha and ubiquitin connections |
| 12:30-13:30 |
Lunch |
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Session II. Protein kinases and therapeutic interventions
Chair: Ruth Palmer, Sweden |
| 14:00-14:30 |
Manuela Baccarini, Austria
Targets of the Raf pathway in tumorigenesis |
| 14:30-15:00 |
Tony Hunter, USA
Signal Transduction in Cancer and the DNA Damage Response |
| 15:00-15:30 |
Coffee break |
| 15:30-16:00 |
Giulio-Superti Furga, Austria
Chemical and pathway proteomics for a postgenomic pharmacology |
| 16:00-16:20 |
Felix Randow, UK
Somatic cell genetics for the study of signalling in innate immunity
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| 16:20-16:40 |
Abigail Miller, USA
The early adenoviral protein E4-ORF1 activates PI3K through the PDZ containing proteins Dlg1, Mint1, Veli-3, and Cask |
| 17:00-19:00 |
Poster session I. |
| 18:00-18:30 |
Meet the Editor I. |
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Free evening |
| May 31 |
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Session III. Targeting signaling networks
Chair: Johannes Bos, Holland |
| 09:00-09:30 |
Tony Pawson, Canada
Adaptors, SH2 domains and tyrosine kinases: Back to the future |
| 09:30-10:00 |
Ruth Palmer, Sweden
Anaplastic Lymphoma Kinase signaling, insights from the fruitfly |
| 10:00-10:20 |
Noriko Gotoh, Japan
Signaling mechanisms in neural stem cells and cancer stem cells |
| 10:20-11:00 |
Coffee break |
| 11:00-11:30 |
Ivan Dikic, Germany
Targeting ubiquitin networks |
| 11:30-12:00 |
Michael B. Yaffe, USA
Integration of Stress Kinase Pathways and DNA Damage Kinase Pathways in Tumor Cells Controls Survival after Genotoxic Stress |
| 12:00-12:20 |
Katrin Rittinger, UK
Vav1 and activation of Rho-family GTPases - a new role for C1 domains? |
| 12:30-15:00 |
Lunch and afternoon swimming break |
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Session IV. Dynamics of signaling pathways
Chair: Manuela Baccarini, Austria
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| 15:00-15:30 |
Marino Zerial, Germany
Genome-Wide Survey of Endocytosis by Quantitative Multi-Parametric Image Analysis |
| 15:30-16:00 |
Johannes Bos, Holland
The regulation and function of Epac proteins |
| 16:00-16:30 |
Coffee break |
| 16:30-17:00 |
Alain Israel, France
Structure-function analysis of NEMO, the core element of the NF-kB cascade |
| 17:00-17:20 |
Marta Miaczynska, Poland
Endocytic Cargo Transport via an APPL-positive Compartment |
| 17:20-17:40 |
Domingo Barber, Spain
Involvement of phosphoinositide 3-kinase γ in T cell receptor-induced T cell activation
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| 18:00-20:00 |
Poster session II. |
| June 1 |
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Session V. Novel technologies in molecular medicine
Chair: Radan Spaventi, Croatia |
| 09:00-09:30 |
Ursula Klingmueller, Germany
Systems Biology and Cancer
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| 09:30-10:00 |
Vishva Dixit, USA
Regulation of Inflammation by ubiquitin modification of signaling components |
| 10:00-10:30 |
Coffee break |
| 10:30-11:00 |
Philippe Bastiaens, Germany
Modulation of palmitoylated Ras signaling via the dynamic acylation cycle |
| 11:00-11:20 |
Bojan Zagrovic, Croatia
Computer simulations in the modern molecular biology research |
| 11:20-11:40 |
Emily Chenette, USA
Signaling Gateway: The Molecule Pages Database
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| 12:00-13:00 |
Lunch |
| 13:30 |
Boat trip to neighboring archipelago
Guided tour and free evening in Dubrovnik |
| 23:00 |
Bus transport from Dubrovnik to Cavtat |
| June 2 |
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Session VI. Molecular biology and medicine I
Chair: Ellen Van Obberghen-Schilling, France
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| 09:00-09:30 |
Maria Masucci, Sweden
Burkitt´s lymphoma: revisiting the pathogenesis of a virus-associated malignancy |
| 09:30-10:00 |
Kohei Miyazono, Japan
TGF-beta signaling and cancer |
| 10:00-10:20 |
Koraljka Husnjak, Germany
Proteasome subunit Rpn13 is a novel ubiquitin receptor |
| 10:20-10:50 |
Coffee break |
| 10:50-11:20 |
Chris Marshall, UK
Rho GTPases, actomyosin contractility and cell migration |
| 11:20-11:50 |
Alfred Wittinghofer, Germany
Signaling via Ras-like G proteins |
| 11:50-12:10 |
Laszlo Nagy, Hungary
The Nuclear Receptors, PPARγ, VDR and RAR Link Lipid Metabolism And Immune Function In Developing Human Dendritic Cells
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| 12:30-14:00 |
Lunch and afternoon break |
| 14:00-14:30 |
Meet the Editor II. |
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Session VII. Molecular biology and medicine II
Chair: Kohei Miyazono, Japan |
| 15:00-15:30 |
Clare Isacke, UK
Tumour : stroma interactions in breast cancer |
| 15:30-16:00 |
Edward Skolnik, USA
Reversible Histidine Phosphorylation of the Potassium Channel KCa3.1 by Nucleoside Diphosphate Kinase B and Protein Histidine Phosphatase-1 Regulates KCa3.1 Activity and the Subsequent Activation of CD4 T Lymphocytes |
| 16:00-16:30 |
Reinhard Faessler, Germany
Genetic analysis of integrin signalling in mice |
| 16:30-17:00 |
Coffee break |
| 17:00-17:30 |
Ellen Van Obberghen-Schilling, France
Cellular fibronectin variants and mechanisms of matrix assembly |
| 17:30-18:00 |
Richard Marais, UK |
| 18:00-18:20 |
Krishnaraj Rajalingam, Germany |
| 18:30-20:30 |
Poster session III. |
| June 3 |
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Session VIII. New trends 2008 - Selected Talks
Chairs: Edward Skolnik, USA and two participants (selection during conference) |
| 09:00-09:20 |
Yvonne Groemping, Switzerland
The structure of the Eps15-Stonin2 complex provides a molecular explanation for EH domain ligand specificity in endocytosis |
| 09:20-09:40 |
Marta Moral, Spain
Generation of a mouse model of human head and neck squamous cell carcinoma through somatic activation of akt kinase and tp53 deficiency |
| 09:40-10:00 |
Tilman Brummer, Germany
The docking protein and proto-oncogene product Gab2 is regulated via a novel negative feedback mechanism mediated by 14-3-3 binding |
| 10:00-10:20 |
Federica Toffalini, Belgium
The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation |
| 10:20-10:50 |
Coffee break |
| 10:50-11:10 |
Mirko Schmidt, Germany
Epidermal growth factor-like 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal |
| 11:10-11:30 |
Pascale Zimmermann, Belgium
Integration of peptide and lipid signaling by PDZ domain scaffold proteins: the syntenin study cases |
| 11:30-11:50 |
Marc Brehme, Austria
Quantitative Characterization of the Bcr-Abl Core Complex amidst its Physical Protein-Protein Interaction Network |
| 11:50-12:10 |
Federica Catalanotti, Austria
MEK1 sets the threshold of ERK activation during growth factor-induced migration |
| 12:30-14:00 |
Lunch and afternoon break |
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Session IX. Communication and society session organized by EMBO
Chair: Ivan Dikic, Germany |
| 14:00-14:30 |
Ania Lichtarowicz, Correspondent, BBC World Service, London, UK
Hitting you in the heart or the pocket: what makes news |
| 14:30-15:00 |
Renee Schröder, Professor, RNA biology, Max F. Perutz Laboratories, Vienna, Austria
The media and me: personal experiences |
| 15:00-15:30 |
Andrew Moore, Manager, EMBO Science & Society Programme, Heidelberg, Germany
Embroidery or embryology, the choice is yours: taking initiatives in media communication |
| 15:30-16:30 |
Beach Practical Course: “How to give an interview for media?”
Andrew Moore – up to 15 student (preregistration required) |
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| 20:00 |
Farewell Dinner
Poster Award Ceremony
Young Investigator Award
Selected Talk Prize
Fun, DJ and Dancing
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